Wireless device to provide new options for colorectal cancer
The researchers utilized photodynamic therapy (PDT) during surgery by using a photosensitizer—a drug activated by light—to kill the cancer cells. During this process, surgeons will be able to remove the bulk of the tumor, then fully irradiate the tumor bed when the photosensitizer is activated by the light. This combination would result in a complete treatment in a safe and effective way with no toxic side effects. The biocompatible, miniaturized implantable LED device will enable light dosing and PDT that is tailored to the individual tumor response.

Researchers have proposed a two-step procedure. First, the photosensitizer drug is administered, which is preferentially taken up by the tumor cells, and then the tumor is illuminated by non-thermal light at a wavelength that matches an absorption spectrum of the drug. Activation of the drug induces a photochemical reaction that triggers tumor cell death.

The intracavity device will provide a minimally invasive, biocompatible platform for light detection of residual cancers and delivery to tumor cells located in any part of the body, suggesting it could make an impact in the areas of breast, kidney, lung, pancreatic, prostate, ovarian and rare cancers

Source: https://www.nature.com/articles/s41467-022-29878-1