Worse diabetes severity increases risk for mortality after s
An exploratory post hoc analysis of a randomized controlled trial in which adults with type 2 diabetes who had an episode of severe hypoglycemia requiring emergency services. Researchers included 124 adults in the analysis, with 60 randomly assigned to the intervention group (55% men; mean age, 74.2 years; mean HbA1c, 7.5%) and 64 randomly assigned to standard care (57.8% men; mean age, 74.8 years; mean HbA1c, 7.6%).

In univariate analysis, Diabetes Severity Score, insulin use and age were significantly correlated with mortality following severe hypoglycemia, whereas no associations were found with CVD at baseline, duration of diabetes, baseline HbA1c, presenting capillary blood glucose, or antiplatelet, antihypertensive and statin therapy.

In multivariate analysis, those with a Diabetes Severity Score of three or four had an increased risk for mortality following severe hypoglycemia compared with those with a score of one or two (adjusted HR = 3.63; 95% CI, 1.78-7.3; P < .001). No other significant associations were observed.

Half of the participants in the standard care group died during the analysis compared with one-third of the intervention participants. The primary cause of death for all participants was infection, followed by CVD. The standard care group had a greater percentage of CVD deaths compared with the intervention group (18.8% vs. 1.7%; P = .002).

Diabetes Severity Score is the only factor significantly linked to greater mortality risk among older adults with type 2 diabetes experiencing severe hypoglycemia.

Source: https://www.healio.com/news/endocrinology/20220510/worse-diabetes-severity-increases-risk-for-mortality-after-severe-hypoglycemia